Molecular imaging enables researchers to investigate the distribution and biological behavior of appropriately designed probes and therapeutic candidates in living systems.
The research question
In vivo evidence answers questions that molecular studies cannot: tissue exposure, targeting in a whole organism, and change over time. This capability is built around interpreting imaging evidence carefully — including what a signal does and does not establish.
Approach and methods
Five areas of work
Probe research and radiolabeling
- Probe design considerations for the target and question
- Radiolabeling strategy and quality checks
- Stability and specificity evaluation
Quantitative preclinical imaging
- Imaging study design matched to the question
- Quantitative acquisition and analysis
- Longitudinal measurement where appropriate
Biodistribution and pharmacokinetics
- Tissue distribution and time-course studies
- Exposure interpretation alongside imaging findings
Target-related imaging and interpretation
- Target-engagement imaging studies
- Integrated interpretation with molecular and PK evidence
- Stated assumptions and signal limitations
Deliverables
What an engagement produces
- Imaging and biodistribution study reports with quantitative results.
- Documented methods, models, and analysis criteria.
- Interpretation of what the signal represents — and its limits.
- Recommendations for confirmatory or follow-up measurements.
Scope and limitations
Feasibility: Study feasibility depends on the candidate, target, model, probe, instrument availability, and scientific objectives, and is confirmed during scoping. Imaging work is coordinated with participating research organizations with the relevant facilities — including ImageNova for preclinical imaging; each is a separate legal entity. AionWell does not claim to provide GMP manufacturing, clinical radiopharmaceutical production, or human imaging.
Relevant applications
Radiopharmaceutical research and precision oncology programs requiring biodistribution, exposure, or target-engagement evidence.
Have an in vivo question imaging could answer?
Tell us the candidate, the target, and what you need the evidence to establish.